Weighted Rank Difference Ensemble: A New Form of Ensemble Feature Selection Method for Medical DatasetsFeature selection (FS), a crucial preprocessing step in machine learning, greatly reduces the dimension of data and improves model performance. This paper focuses on selecting features for medical data classification. Methods: In this work, a new form of ensemble FS method called weighted rank difference ensemble (WRD-Ensemble) has been put forth. It combines three FS methods to produce a stable and diverse subset of features. The three base FS approaches are Pearson’s correlation coefficient (PCC), reliefF, and gain ratio (GR). These three FS approaches produce three distinct lists of features, and then they order each feature by importance or weight. The final subset of features in this study is chosen using the average weight of each feature and the rank difference of a feature across three ranked lists. Using the average weight and rank difference of each feature, unstable and less significant features are eliminated from the feature space. The WRD-Ensemble method is applied to three medical datasets: chronic kidney disease (CKD), lung cancer, and heart disease. These data samples are classified using logistic regression (LR). Results: The experimental results show that compared to the base FS methods and other ensemble FS methods, the proposed WRD-Ensemble method leads to obtaining the highest accuracy value of 98.97% for CKD, 93.24% for lung cancer, and 83.84% for heart disease. Conclusion: The results indicate that the proposed WRD-Ensemble method can potentially improve the accuracy of disease diagnosis models, contributing to advances in clinical decision-making.; February 2024